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. 2005 Dec;11(12):1898–1908. doi: 10.1261/rna.2192805

FIGURE 4.

FIGURE 4.

Changes in DMS reactivity in 40S subunits when bound to HCV IRES or H3V RNAs. (A) DMS chemical probing results of 40S with the HCV IRES and H3V RNAs. Nucleotides with enhanced reactivity in the HCV IRES or H3V RNA complexes relative to the 40S subunits aloneare indicted by squares. (B) Changes in solvent accessibility upon binding of the HCV IRES to 40S ribosomal subunits in the central domain mapped onto the secondary structure of the 18S rRNA. Enhancements, protections, and secondary structural elements are marked as in Figure 3. Helix 27 (h27, E. coli numbering) is indicated.