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. 2006 Feb 21;3(4):e101. doi: 10.1371/journal.pmed.0030101

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Copyright: © 2006 Ieraci and Herrera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Western blot analysis of cytochrome-c release in the cytosolic fraction 12 h after ethanol administration.

(C) Densitometric quantification of cytochrome-c release (ANOVA F _3,20 = 43.546 p < 0.0001; n = 6 each treatment group). Values are shown as mean ± SD. Bonferroni correction for multiple comparison revealed a significant difference between ethanol treatment group and all other groups. ∗ p < 0.0001.

(B and D) Nicotinamide (1mg/g) does not alter ethanol absorption or excretion. Ethanol levels in blood (B) and brain (D) were measured at different time points after 5g/kg of ethanol treatment in P7 mice. Nicotinamide was administered 2 h after ethanol exposure. No significant differences were seen between the different treatments ( n = 4 each treatment group).