. Author manuscript; available in PMC: 2006 Feb 17.

Published in final edited form as: N Engl J Med. 2002 Feb 7;346(6):393–403. doi: 10.1056/NEJMoa012512

Table 3.

Adverse Events.

Event	Placebo	Metformin	Lifestyle
Gastrointestinal symptoms (no. of events/100 person-yr)^*	30.7	77.8^†	12.9^†
Musculoskeletal symptoms (no. of events/100 person-yr)^‡	21.1	20.0	24.1^†
Hospitalization
One or more admissions (% of participants)	16.1	15.9	15.6
Rate (no. of admissions/100 person-yr)	7.9	8.4	8.0
Median stay (days)	3	3	3
Deaths (no./100 person-yr)	0.16	0.20	0.10

Gastrointestinal symptoms included diarrhea, flatulence, nausea, and vomiting.

^†

P<0.0167 for the comparison with placebo.

^‡

Most participants with musculoskeletal symptoms had myalgia, arthritis, or arthralgia.