Table 6.

Sleep onset latency (minutes) in people with sleep disorders accompanying sleep restriction

Study	Design	Method of computing SE of difference between melatonin and placebo	Melatonin		Placebo
			No	Mean (SD)	No	Mean (SD)	Mean (95% CI) difference
Beaumont et al, 200426	Parallel	From SDs	9	29.7 (14.0)	9	32.2 (14.3)	−2.6 (−15.7 to 10.5)
Folkard et al, 199329	Crossover	SDs using estimated correlation of 0.5	7	4.5 (1.6)	7	5.6 (1.8)	−1.1 (−2.3 to 0.2)
James et al, 199830	Crossover	From exact P value of difference	22	15 (7.0)	22	16 (9.0)	−1.0 (−5.7 to 3.7)
Jockovich et al, 200031	Crossover	From exact P value of difference	19	7.6 (not provided)	19	6.8 (not provided)	0.8 (−2.7 to 4.3)
Jorgensen and Witting, 199832	Crossover	From confidence interval of difference	18	13.6 (not provided)	18	15.6 (not provided)	−2.0 (−7.5 to 3.5)
Suhner et al, 199835	Parallel	Estimated from upper bound of P value	174	19.4 (not provided)	60	32.1 (not provided)	−12.6 (−25.2 to −0.1)
Suhner et al, 200136	Parallel	From SDs	35	21.7 (23.7)	39	21.2 (27.3)	0.5 (−11.1 to 12.1)
Waldhauser et al, 199037	Parallel	Estimated from upper bound of P value	10	14.7 (not provided)	10	23.7 (not provided)	−9.0 (−19.2 to 1.2)
Wright et al, 199838	Crossover	SDs using estimated correlation of 0.5.	15	22.3 (14.2)	15	19.0 (13.7)	3.3 (−3.8 to 10.4)