. 2026 Jul 30;49(6):140. doi: 10.1007/s13402-026-01268-5

Table 2.

Correlation between HIF-1α Expression and Clinicopathological Parameters in HNSCC

Clinical Feature	Total	HIF-1α Expression		χ²	P Value
Clinical Feature	Total	Low	High	χ²	P Value
Gender
Male	77	61	16	0.846	0.358
Female	31	22	9	0.846	0.358
Age
≤ 60	76	61	15	1.678	0.195
>60	32	22	10	1.678	0.195
Differentiation Degree
High	52	45	7	5.289	0.021*
Medium&Low	56	38	18	5.289	0.021*
TNM Stage
Stage I - II	44	38	6	3.776	0.052
Stage III - IV	64	45	19	3.776	0.052
Lymph Node Metastasis
No	71	58	13	2.727	0.099
Yes	37	25	12	2.727	0.099
Nerve Invasion
No	65	53	12	2.016	0.156
Yes	43	30	13	2.016	0.156
Lymphatic Invasion
No	60	48	12	0.752	0.386
Yes	48	35	13	0.752	0.386
Vascular Embolism
No	103	78	25	1.579	0.209
Yes	5	5	0	1.579	0.209

(*P < 0.05)