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. Author manuscript; available in PMC: 2006 Feb 17.
Published in final edited form as: Angiogenesis. 2003;6(3):241–249. doi: 10.1023/B:AGEN.0000021401.58039.a9

Figure 1.

Figure 1.

Pericyte tubes are a component of tumor microvasculature. Frozen sections were taken from spontaneous MMTV-PyMT breast carcinoma (a-c), subcutaneous Lewis lung carcinoma (d-f), and subcutaneous PC-3 prostate tumor (g-i). Vascular endothelial elements (red) are identified by combined immunohistochemical staining for CD31, CD105, and flk-1. Pericytes (green) are identified by staining for NG2 proteoglycan. All panels are Z-stack confocal images. All three tumor types contain endothelium-free pericyte tubes, labeled by Δ in the merged images of panels c, f and i. The margins of complete pericyte tubes are indicated with arrows in c and i. In f the entire segment is a pure pericyte tube. Note the absence of endothelium (a, d, g and c, f, i) in regions that contain pericyte tubes (b, e, h). Scale bars indicate 10 μm.