Table 2. Values of gelation temperature (n = 3), gelling capacity (n = 3), pH (n = 4), viscosity (n = 4), drug content (n = 3), and score of clarity (n = 3).
|
Formulation |
Gelling capacity |
Gelling temperature (°C) |
Clarity |
pH |
Viscosity (cP) |
Drug content (%) |
|
N1 |
### |
35.167 ± 0.289A |
+ |
7.095 ± 0.013B |
422.425 ± 0.846D* |
98.686 ± 0.315B |
|
N2 |
### |
32.500 ± 0.500B |
+ |
7.085 ± 0.013B |
883.750 ± 3.676C* |
97.697 ± 0.116C |
|
N3 |
### |
32.000 ± 0.000B |
+ |
7.093 ± 0.036B |
1196.250 ± 4.272B* |
97.072 ± 0.075D |
|
N4 |
### |
30.000 ± 0.000C |
+ |
7.198 ± 0.005A |
3622.500 ± 15.000A** |
100.348 ± 0.046A |
Values are expressed as mean ± standard deviation.
A-DWithin each column, values not sharing a common superscript letter differ significantly (one-way ANOVA followed by Tukey’s multiple comparisons test, p < 0.05). Letters are assigned in descending order of the mean and are independent for each column. Gelling capacity and clarity were scored qualitatively and were identical for all formulations; therefore no statistical comparison was performed for these parameters.
#, gel developed after a short delay but quickly liquefied; ##, gel formed instantly and lasted for several minutes; ###, rapid gel formation that remained intact for approximately one hour.
+++, very clear (glassy); ++, clear; +, turbid.
*measured at 60 rpm; **measured at 10 rpm. These symbols denote the rotational speed of the measurement only and carry no statistical meaning.
ANOVA, analysis of variance.