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. 2026 Oct 26;26:1302. doi: 10.1186/s12885-026-17178-6

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Endothelial p16 expression in ccRCC with clinicopathological parameters and survival. a Representative CD31 and p16 staining of small nest and thick trabecular growth patterns with low (< 35%) and high (≥ 35%) vascular p16 expression. b Kaplan-Meier analysis of overall survival according to the proportion of p16 positive endothelial cells and p16 expression. c Distribution of growth patterns according to p16 vessel expression (d) Correlation matrix of clinicopathological parameters, growth patterns and p16 expression