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. 2026 Oct 14;16:1942820. doi: 10.3389/fonc.2026.1942820

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Copyright © 2026 Li, Zhou, Wu, Xiao, Li, Zhou, Wu, Wang, Liao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panel a shows a volcano plot with log2 fold change on the x-axis and negative log10 p-value on the y-axis, highlighting upregulated (red) and downregulated (blue) genes. Panel b displays a hierarchical clustering heatmap of gene expression with samples and genes represented in clustered dendrograms and a blue-to-red color scale for expression values. Panel c presents a Venn diagram comparing differentially expressed genes (DEGs) between two datasets, with 6,823 unique to GSE288878, 521 unique to the cohort, and 5 overlapping. — A shared gene signature linked to CRPC-related cell types was extracted from the overlap among DEGs identified in our cohort and GSE288878 datasets, yielding five overlapping genes: SLC25A39, GRB10, SELENBP1, SLC6A8, and YBX3. (a) Volcano plot of DEGs in our cohort; (b) heatmap for DEGs; (c) Venn diagram identifying the final five intersection genes).