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. 2002 Oct 15;30(20):4470–4480. doi: 10.1093/nar/gkf575

Figure 1.

Figure 1

Telomeric DNA synthesis catalysed by human telomerase. (A) Telomerase catalytic protein (hTERT) is shown with the template sequence spanning nucleotides +46 to +56 of the RNA subunit (hTR) and the anchor site. (B) Primer annealing: the 3′ end of the primer base pairs with the template region of telomerase RNA. (C) Primer extension by reverse transcription until the 5′ end of the template is reached. Newly synthesised DNA is indicated in bold. (D) Translocation and re-alignment of the primer terminus to the 3′ end of the template for a further round of extension. For non-natural substrates, primer annealing during first round synthesis is dictated by sequence complementarity between the primer 3′ end and the template region. In subsequent rounds of synthesis, re-alignment of the primer 3′ end is as described above (D).