Table 1. Nomenclature, modifications and activity of the human telomerase RNA mutants.
| hTR mutant | Specific nucleotide change | Alignment domain | Telomerase activity (%) (±SD) |
|---|---|---|---|
| Wild-type | None | 56CAAUC52 | 100 |
| Δ1 | Δ56C | AAUC52 | 84 ± 8 |
| Δ2 | Δ56CA | AUC52 | 43 ± 9 |
| Δ3 | Δ56CAA | UC52 | 0 |
| Δ4 | Δ56CAAU | C52 | 0 |
| Δ5 | Δ56CAAUC | None | 0 |
| Sub1 | 56C→G | AAUC52 | 77 ± 3 |
| Sub2 | 56CA→GT | AUC52 | 37 ± 7 |
| Sub3 | 56CAA→GTT | UC52 | 0 |
| Sub4 | 56CAAU→GTTA | C52 | 0 |
| Sub5 | 56CAAUC→GTTAG | None | 0 |
| RRL control | 0 |
Δ, deletion; Sub, substitution. The sequence of the alignment domain is written 3′→5′. The values for activity are background corrected with respect to the RRL control (which showed 3 ± 1% activity) and normalised with respect to the wild-type (taken as 100%). The values for activity represent the mean of at least three independent experiments.