Table 1. TPA-induced temporal gene expression in HL-525 cellsa.
| GenBank accession no. | Gene name and description | Expression |
|---|---|---|
| Early response genes | ||
| AA446018 | Ini1, subunit of SWI/SNF chromatin remodeling complex | ↑ |
| AA029890 | PKCα | ↑ |
| AA284954 | Colony stimulating factor 1 receptor | ↑ |
| AA454947 | AKAP149 | ↑ |
| AA626845 | DEAD-box RNA helicase (DDX3) | ↑ |
| AA405569 | Fibroblast activating protein, dipeptidyl peptidase and gelatinase | ↑ |
| R01238 | Tip associating protein, transport | ↑ |
| AA454094 | Cullin (Cul-2), interacts with VHL/elongin B and C to form an ubiquitin-ligase complex | ↑ |
| H80712 | Caspase 10 | ↑ |
| H77651 | GATA-6, transcription factor | ↑ |
| Intermediate response genes | ||
| AA454585 | Splicing factor, arginine/serine rich-2 (SFRS2) | ↑ |
| W72693 | hnRNP A/B (ABBP1), splicing | ↑ |
| AA040170 | Monocyte chemotactic protein 3 | ↑ |
| AA262719 | Protein tyrosine phosphatase, non-receptor type 7 | ↑ |
| H85962 | JNK kinase 2 (JNKK2) | ↑ |
| W45690 | Mitogen-activated protein kinase 1 | ↑ |
| AA454612 | Huntingtin, microtubule-mediated transport or vesicle function | ↑ |
| R89082 | AKAP18 | ↑ |
| AA459308 | Elastin | ↑ |
| H50344 | Tight junction protein | ↑ |
| R89567 | Vitamin D binding protein | ↑ |
| AA703141 | Protein 4.1 | ↑ |
| AA019320 | Adducin 2 | ↑ |
| Late response genes | ||
| N21576 | Mitochondrial 1,25-dihydroxyvitamin D3 24-hydroxylase | ↑ |
| AA664389 | TSC-22, TGFβ-stimulated protein | ↑ |
| H44953 | Caspase-4 | ↑ |
| H96235 | v-ets avian erythroblastosis virus E2 oncogene homolog 2 (ETS-2) | ↑ |
| AA436163 | Prostaglandin E synthase | ↑ |
| T53298 | Prostacyclin-stimulating factor | ↑ |
| T49652 | 5-Lipoxygenase activating protein | ↑ |
| AA496780 | Rab7, endocytic transport | ↑ |
| AA487593 | Transferrin receptor | ↑ |
| AA486112 | Vacuolar H+-ATPase | ↑ |
aExpression of these genes is not affected in HL-60 cells.