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(A) A line drawing of immunomer showing CpG dinucleotide directionality and different linkers used to tether two CpG DNAs for synthesis of immunomers. (B) Schemes showing (i) linear synthesis of CpG DNA and immunomers, and parallel synthesis of immunomers using (ii) diDMT protected brancher phosphoramidite or (iii) solid support attached diDMT protected brancher. N stands for any nucleoside.
