Table 2. Concentration-dependent cytokine secretion in BALB/c mouse spleen cell cultures by immunomers.
| CpG DNA | IL-12 (pg/ml) ± SD | IL-6 (pg/ml) ± SD | ||||||
|---|---|---|---|---|---|---|---|---|
| 0.1 µg/ml | 0.3 µg/ml | 1.0 µg/ml | 3.0 µg/ml | 0.1 µg/ml | 0.3 µg/ml | 1.0 µg/ml | 3.0 µg/ml | |
| 10 | 70 ± 13 | 444 ± 33 | 1142 ± 100 | 2570 ± 46 | 150 ± 8 | 211 ± 26 | 3979 ± 514 | 21491 ± 1951 |
| 15 | 189 ± 24 | 1404 ± 189 | 2972 ± 275 | 2910 ± 191 | 314 ± 56 | 456 ± 21 | 2550 ± 356 | 20923 ± 103 |
| 20 | 70 ± 8 | 1025 ± 36 | 2135 ± 96 | 2155 ± 128 | 211 ± 51 | 533 ± 4 | 2696 ± 138 | 17918 ± 1495 |
| 21 | 217 ± 56 | 1397 ± 42 | 2443 ± 48 | 2921 ± 64 | 183 ± 22 | 452 ± 15 | 3812 ± 96 | 23894 ± 713 |
| 22 | 504 ± 58 | 1609 ± 132 | 2428 ± 226 | 2743 ± 269 | 233 ± 5 | 1965 ± 1 | 9307 ± 95 | 26825 ± 1239 |
| 23 | 103 ± 22 | 1417 ± 76 | 2385 ± 168 | 3482 ± 81 | 198 ± 57 | 376 ± 82 | 7537 ± 964 | 24827 ± 1917 |
| 24 | 34 ± 3 | 135 ± 18 | 1351 ± 106 | 3282 ± 115 | NT | |||
| Culture medium | 71 ± 1 | 155 ± 28 | ||||||
NT, not tested.