Table 4. Effect of multiple linkers on cytokine secretion in BALB/c mouse spleen cell cultures.
| CpG DNA | IL-12 (pg/ml) ± SD | IL-6 (pg/ml) ± SD | ||||||
|---|---|---|---|---|---|---|---|---|
| 0.1 µg/ml | 0.3 µg/ml | 1.0 µg/ml | 3.0 µg/ml | 0.1 µg/ml | 0.3 µg/ml | 1.0 µg/ml | 3.0 µg/ml | |
| 10 | 310 ± 1 | 1962 ± 78 | 3780 ± 805 | 6084 ± 1390 | 181 ± 57 | 582 ± 143 | 5981 ± 138 | 13879 ± 612 |
| 29 | 4118 ± 1099 | 5768 ± 1250 | 8042 ± 632 | 7414 ± 457 | 421 ± 30 | 806 ± 131 | 4725 ± 291 | 15093 ± 636 |
| 34 | 4005 ± 174 | 6488 ± 1123 | 8112 ± 270 | 6858 ± 251 | 276 ± 26 | 2581 ± 285 | 7033 ± 743 | 15958 ± 2371 |
| 35 | 3917 ± 677 | 6156 ± 728 | 5806 ± 365 | 6782 ± 539 | 660 ± 144 | 1908 ± 268 | 8223 ± 378 | 12319 ± 468 |
| 33 | 778 ± 136 | 4854 ± 498 | 6563 ± 358 | 8803 ± 666 | 294 ± 107 | 587 ± 56 | 6359 ± 372 | 17006 ± 1274 |
| 36 | 1812 ± 150 | 4879 ± 432 | 4874 ± 170 | 6126 ± 253 | 331 ± 18 | 1348 ± 128 | 5823 ± 330 | 12888 ± 1186 |
| 37 | 2994 ± 46 | 5293 ± 544 | 5341 ± 456 | 5602 ± 91 | 408 ± 8 | 1310 ± 82 | 5764 ± 748 | 12470 ± 1373 |
| Culture medium | 256 ± 42 | 82 ± –17 | ||||||