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. 2026 Oct 14;17:1903348. doi: 10.3389/fneur.2026.1903348

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Copyright © 2026 Alesefir, Hejazi, Alashger, Abodahab, Abdelrazek, Abouelnaga, Koudeimati, Alshibani and Aljohani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neurologist-focused clinical workflow for ICANS is depicted in five color-coded steps: before therapy (baseline history, exam, language, high risk), peak-risk monitoring (bedside checks, ICE, language review every eight to twelve hours), triggered escalation (neurology consult for specific symptoms), targeted testing (EEG, MRI, labs, or CSF only when results change treatment), and product-aware treatment (escalate therapy, treat seizures, extended surveillance for BCMA syndromes). A practice pearl below emphasizes using ancillary tests only if results affect management, intensive care transfer, or diagnosis. — Neurologist-focused clinical workflow across CAR T-cell and CD3-engaging bispecific-antibody therapy.