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. 2026 Oct 14;17:1903348. doi: 10.3389/fneur.2026.1903348
Dimension Included Excluded
Population Recipients of CAR T-cell or CD3-engaging bispecific-antibody therapy Other therapies or populations without relevant immune effector exposure
Intervention/exposure CAR T-cell therapy; CD3-engaging bispecific antibodies Preclinical exposure without directly applicable clinical findings
Comparator Not required Not applicable
Outcomes ICANS recognition/grading; serial monitoring; EEG/imaging; timing; neurologic management/mitigation; outpatient workflows; delayed BCMA syndromes No ICANS or extractable clinically relevant neurologic outcome
Study type Consensus guidance, reviews, meta-analyses, trials, observational studies, real-world cohorts, pilots, clinically informative case reports Conference abstracts, editorials, commentaries, preprints, non-peer-reviewed reports, overlapping reports without additional findings
Language English Non-English