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PPG nucleoside prevents aggregation in G-rich ODNs. (A) Structure of a G-tetrad showing Hoogsteen H-bonds to N-7 of G. (B) Structure of the PPG nucleoside [6-amino-1-(4-hydroxy-5-hydroxy methyl-tetrahydro-furan-2-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one, a substitute for G].
