Table 11.
Integrated outcome-level synthesis of the umbrella evidence.
| Outcome | Significant reviews | GRADE (M/L/VL) | AMSTAR 2 (H/M/L/CL) | Brief interpretation |
|---|---|---|---|---|
| BBS | 17/19 | 3/10/6 | 3/6/6/4 | Consistent benefit; most evidence low/very low. Clinical importance varied (MCID ~6.5–12.5 points) (33). |
| FMA-LE | 13/15 | 5/7/3 | 1/5/5/4 | Direction was mostly favorable. MIC/MCID is phase-dependent (~3.3–4.3 p Mostly favorable); MIC/MCID is phase-dependent (~3.3–4.3 acute; ~6 chronic) (34, 35). |
| FAC | 10/13 | 3/7/3 | 2/6/4/1 | Generally favorable but inconsistent and mainly low certainty; a universal stroke-specific MCID is not established. |
| 6MWT | 7/10 | 5/3/2 | 1/5/40 | Mixed; some estimates reached reported MCIDs (~34–71 m), whereas others did not (37). |
| TUG | 2/8 | 2/3/3 | 2/4/2/0 | Mostly non-significant; additional benefit remains uncertain. |
| 10MWT | 4/5 | 1/3/1 | 1/2/ 2/0 | Often statistically favorable, but mostly low certainty; clinical importance varied (~0.16 m/s benchmark) (36). |
M/L/VL, moderate/low/very low GRADE certainty; H/M/L/CL, high/moderate/low/critically low AMSTAR 2 quality. Counts indicate review-level concordance, not independent replications, because primary RCTs overlap. MCID/MIC comparisons are contextual and phase-dependent.