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. 2026 Oct 16;14:1969488. doi: 10.3389/fpubh.2026.1969488

Table 11.

Integrated outcome-level synthesis of the umbrella evidence.

Outcome Significant reviews GRADE (M/L/VL) AMSTAR 2 (H/M/L/CL) Brief interpretation
BBS 17/19 3/10/6 3/6/6/4 Consistent benefit; most evidence low/very low. Clinical importance varied (MCID ~6.5–12.5 points) (33).
FMA-LE 13/15 5/7/3 1/5/5/4 Direction was mostly favorable. MIC/MCID is phase-dependent (~3.3–4.3 p Mostly favorable); MIC/MCID is phase-dependent (~3.3–4.3 acute; ~6 chronic) (34, 35).
FAC 10/13 3/7/3 2/6/4/1 Generally favorable but inconsistent and mainly low certainty; a universal stroke-specific MCID is not established.
6MWT 7/10 5/3/2 1/5/40 Mixed; some estimates reached reported MCIDs (~34–71 m), whereas others did not (37).
TUG 2/8 2/3/3 2/4/2/0 Mostly non-significant; additional benefit remains uncertain.
10MWT 4/5 1/3/1 1/2/ 2/0 Often statistically favorable, but mostly low certainty; clinical importance varied (~0.16 m/s benchmark) (36).

M/L/VL, moderate/low/very low GRADE certainty; H/M/L/CL, high/moderate/low/critically low AMSTAR 2 quality. Counts indicate review-level concordance, not independent replications, because primary RCTs overlap. MCID/MIC comparisons are contextual and phase-dependent.