Table 2.

Pharmacokinetic parameters

Parameter	Definition
Cmax	Maximum plasma concentration obtained directly from the data without interpolation.
Tmax	Time to reach Cmax directly from the data without interpolation.
AUC0-last	The area under the drug concentration-time curve, from time zero to time of the last measurable concentration, calculated by the “linear up and log down” method.
AUC0-inf	Area under the drug concentration-time curve, from time zero extrapolated to infinity.
AUC0-12h	Area under the drug concentration-time curve, from time 0 h to 12 h, calculated by the “linear up and log down” method.
AUC0-24h	Area under the drug concentration-time curve, from time 0 h to 24 h, calculated by the “linear up and log down” method.
AUC%extrap	The percentage of the AUC that was extrapolated beyond the last observed data point.
t1/2	Apparent plasma terminal elimination half-life.
λz or Kel	The apparent terminal elimination rate constant.
CL/F	Apparent total plasma clearance.
Vz/F	Apparent terminal volume of distribution.

K_el, elimination rate constant. Values for λ_z, t_1/2, AUC_0-inf, AUC_%extrap, CL/F, and Vz/F were not reported for cases that did not exhibit a terminal log-linear phase in the concentration versus time profile.