IHL-42X was generally well tolerated and biovailable when administered with or without food.

Some parameters, such as maximum plasma concentration (Cmax) for acetazolamide and area under curve from zero to last measurable concentration (AUC0–last) for tetrahydrocannabinol, did not meet bioequivalence criteria.

These findings support the oral delivery of both DRN and ACZ from the formulations.