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. 2026 Oct 3;17:11324. doi: 10.1038/s41467-026-77941-y

Fig. 3. High-throughput screening reveals disrupted RAD51D interaction surfaces.

Fig. 3

a Surface representation of RAD51D within the BCDX2 complex (PDB: 8GBJ). Surface residues are colored according to either red (50% pathogenicity) or yellow (20% pathogenicity). Cartoon representations of XRCC2 (purple), RAD51D (light blue), RAD51C (green), and RAD51B (red) are shown consistently throughout. Bound ATP molecules are represented as yellow-orange sticks. b Specific loss-of-function variants (red, 50% pathogenicity) listed above or (yellow, 20% pathogenicity) listed below the RAD51D schematic are shown with the indicated interaction interfaces indicated. c–g) Binding sites for RAD51C (c), ATP site 1 (d), XRCC2 (e), ssDNA (f), and ATP site 2 (g).