Table 2.

Functionally abnormal RAD51D clinical VUS

Patient Info				RAD51D VUS		Assay results
Current Age	Personal History of Cancer	Age at diagnosis	Family History of Cancer	cDNA	AF	MAVE score	Classification
60–64	Ovarian cancer	60-64	Unilateral breast, dx 40 s	c.802 T > A (p.Trp268Arg)	1.4 × 10-6	−1.410	Abnormal
55–59	Triple-negative breast cancer	55-59	Colon, dx 70 s	c.823 C > T (p.Arg275Trp)	9.6 × 0-6	−1.278	Abnormal
30–34	None	N/A	N/A	c.11 T > C (p.Leu4Pro)	N/A	−0.648	Abnormal