Table 2.
Characteristics of the internal validation subset participants
| Characteristics | Cerebellar cortical Aβ + (cerebellar SUVRWM ≥ 0.428) |
Cerebellar cortical Aβ − (cerebellar SUVRWM < 0.428) |
P |
|---|---|---|---|
| No. of subjects | 19 | 11 | - |
| Age (years), mean (SD) | 64.26 (7.51) | 64.09 (10.01) | > 0.999 |
| Female, n (%) | 14 (73.7) | 6 (54.5) | 0.425 |
| MMSE score, mean (SD) | 17.53 (5.20) | 14.45 (6.96) | 0.539 |
| MoCA score, mean (SD) | 11.68 (5.49) | 10.00 (6.63) | 0.725 |
| APOE status | 15 | 10 | 0.442 |
| ε4 Carriers, n (%) | 10 (66.7) | 5 (50.0) | - |
| ε4 Non-carriers, n (%) | 5 (33.3) | 5 (50.0) | - |
| Cerebellar SUVRWM, mean (SD) | 0.45 (0.01) | 0.40 (0.02) | < 0.001 |
| CSF tests | |||
| Aβ-42 (pg/ml), mean (SD) | 469.09 (115.30) | 534.65 (126.61) | 0.539 |
| T-tau (pg/ml), median (IQR) | 417.32 (245.92, 551.48) | 419.79 (306.31, 547.20) | > 0.999 |
| P-tau181 (pg/ml), mean (SD) | 94.34 (39.15) | 83.31 (44.00) | 0.725 |
| Aβ-42/Aβ-40, mean (SD) | 0.04 (0.02) | 0.05 (0.02) | 0.929 |
| P-tau181/Aβ-42, median (IQR) | 0.19 (0.14, 0.24) | 0.17 (0.09, 0.21) | 0.691 |
| Visual positive, n (%)a | 18 (94.7) | 1 (9.1) | - |
Data were presented as mean (SD) or median (IQR). Group comparisons: independent t-test (age, MMSE, MoCA, cerebellar SUVRWM, CSF Aβ-42, CSF P-tau181, CSF Aβ-42/Aβ-40), Mann–Whitney U test (CSF T-tau, P-tau181/Aβ-42), chi-square test (gender, APOE status)
a Visual assessment in the internal validation subset was adjudicated by the third reader
Abbreviations: SD Standard deviation; IQR Interquartile range; MMSE Mini-Mental State Examination; MoCA Montreal Cognitive Assessment; APOE Apolipoprotein E; SUVR Standardized uptake value ratio; WM White matter; Aβ Amyloid-beta; CSF Cerebrospinal fluid; T-tau Total tau; P-tau181 Phosphorylated tau 181