Table 2. Patient demographics and hemophilia characteristics.
|
Patient No. |
Sex/Age (yr) |
Diagnosis |
Severity |
Factor level (%) |
Inhibitor |
Inhibitor titer (BU) |
Clotting factor product |
Maintenance therapy |
|---|---|---|---|---|---|---|---|---|
|
Patient 1 |
M/19 |
Hemophilia A |
Moderate |
1.7 |
Negative |
- |
Adynovate |
2,000 U every 2-3 days |
|
Patient 2 |
M/55 |
Hemophilia A |
Mild |
10.0 |
Negative |
- |
GreenGene F |
PRN |
|
Patient 3 |
M/18 |
Hemophilia B |
Mild |
10.0 |
Negative |
- |
Rixubis |
4,000 U, 7×/4 weeks |
|
Patient 4 |
M/18 |
Hemophilia A |
Unknown1 |
Unknown1 |
Negative |
- |
Adynovate |
PRN (procedure only) |
|
Patient 5 |
M/18 |
Hemophilia A |
Severe |
0.7 |
Negative |
- |
Adynovate |
2,000 U, 2×/week |
|
Patient 6 |
M/36 |
Hemophilia A |
Severe |
0.5 |
Negative |
- |
Afstyla |
1,500-2,000 U, 2-3×/week |
|
Patient 7 |
M/14 |
Hemophilia A |
Mild |
10.0 |
Negative |
- |
Advate |
PRN (procedure only) |
|
Patient 8 |
M/34 |
Hemophilia A |
Severe |
0.2 |
Negative |
- |
Advate |
2,250 U, 1-2×/week |
|
Patient 9 |
M/70 |
Hemophilia A |
Moderate |
1.7 |
Negative2 |
- |
Advate |
PRN; Advate 4,000 U |
|
Patient 10 |
M/70 |
Hemophilia A |
Severe |
0.7 |
Positive |
5.88 |
FEIBA |
PRN (inhibitor patient) |
|
Patient 11 |
M/20 |
Hemophilia B |
Severe |
0.3 |
Negative |
- |
BeneFIX |
9,000 U, 1×/week |
|
Patient 12 |
M/45 |
Hemophilia A |
Severe |
0.3 |
Negative |
- |
Green Mono |
1,000-1,250 U, 3×/week |
|
Patient 13 |
M/32 |
Hemophilia A |
Severe |
0.2 |
Negative |
- |
Advate |
2,500 U, 1-2×/week |
(M: male, BU: Bethesda units, PRN: pro re nata [as needed], -: not available)
1Patient 4: factor level not documented in available records.
2Patient 9: transient inhibitor in 2019 (0.82 BU); confirmed negative on repeated testing November 2019 to August 2023; Advate used at time of surgery.
Age is at the first surgical case.