Table 2.

A comparison of previously reported cases of ocular infections caused by S. aurantiacum.

Author information	Kim et al. (2)	Li et al. (14)	Carnovale et al. (1)	Present study
Antifungal	MIC (µg/mL)/the method used for MIC determination
Amphotericin B	16 CLSI	NR	8 CLSI	2/SENS
Fluconazole	—	NR	—	8/SENS
Itraconazole	16 CLSI	NR	0.5 CLSI	0.12/SENS
Posaconazole	2 CLSI	NR	0.5 CLSI	0.12/SENS
Voriconazole	1 CLSI	NR	0.25 CLSI	0.38/ETEST
Isavuconazole	—	NR	2 CLSI	NR
Caspofungin	8 CLSI	NR	NR	NR
Micafungin	8 CLSI	NR	NR	NR
5-fluorocytosine	NR	NR	NR	>64 SE
Patient age, gender	70 years, woman	67 years, female	4 years, female	80 years, female
Predisposing factors	Mild eye injury due to soil exposition	Previous pterygium surgery with conjunctival autograft	Penetrating trauma by kitchen instrument	Lateral tarsorrhaphy of the right eyelids
Type of ocular infection	Infectious scleritis with corneal ulcer	Infectious scleritis with vitritis	Post-traumatic endophthalmitis	Keratitis
Identification/time to diagnosis	Culture and sequencing of the ITS region and the 26S rRNA gene/12 days	Culture/6 weeks	Culture and sequencing of the β-tubulin gene/15 days	Culture and MALDI-TOF MS/9 days
Country/region	Republic of Korea	Australia, Queensland	Argentina	Czech Republic
Targeted therapy	Topical voriconazole and amphotericin B, IV voriconazole	Topical + intravitreal + PO voriconazole	Voriconazole	Topical + oral voriconazole
Surgical intervention	Evisceration and enucleation	Enucleation	Surgery for corneal trauma	Evisceration
Follow-up duration	NR	NR	NR	3 years
Final visual outcome	Loss of eye	Loss of eye	A favorable clinical outcome	Loss of vision

CLSI, CLSI Standards M38 Reference method for broth dilution antifungal susceptibility testing of filamentous fungi ETEST, E-test, SENS, Sensititre YeastOne, NR, not reported.