Table 2.

Linear regression analysis for the moderation effect of GAD on the relationship between MIP1α and NIHSS in total stroke patients.

	Mode 1 (NIHSS)		Model 2 (NIHSS)		Model 3 (NIHSS)
	Standardized β	t value	Standardized β	t value	Standardized β	t value
Age	−0.18**	−2.81	−0.20**	−3.15	−0.19**	−3.09
Sex	−0.02	−0.19	−0.05	−0.62	−0.06	−0.69
Smoking	−0.01	−0.07	0.02	0.19	0.01	0.17
Drinking	0.02	0.31	−0.01	−0.12	−0.01	−0.14
Diabetes	0.07	1.21	0.07	1.25	0.07	1.19
Hypertension	−0.07	−1.20	−0.07	−1.15	−0.06	−1.07
GAD-7 group	—	—	0.24***	3.92	0.24***	3.97
MIP-1α	—	—	−0.18**	−3.10	−0.19**	−3.28
MIP-1α × GAD-7	—	—	—	—	0.16**	2.75
Adjusted R²	0.02		0.10***		0.13***
F	1.96		4.80		5.22

All data were centered and standardized prior to analysis. Anxiety symptom group was coded as 0 for GAD-7 ≤4 and 1 for GAD-7 >4. Model 1 was a linear regression model including Age, Sex, Smoke and Drink as the independent variables, with NIHSS as the dependent variable. Model 2 was another linear regression model that included GAD and MIP1α as the inde- pendent variables, with NIHSS as the dependent variable. Model 3 included GAD, MIP1α, GAD×MIP1α terms as independent variables and NIHSS as the dependent variable. Both Model 2 and the Model 3 were adjusted for Age, Sex, Smoke and Drink. **p <0.01, ***p <0.001.

GAD, Generalized Anxiety Disorder Scale; NIHSS, National Institutes of Health Stroke Scale; MIP-1α, Macrophage Inflammatory Protein-1α; MCP-1, Monocyte Chemoattractant Protein-1; MIP-1β, Macrophage Inflammatory Protein-1β.