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. Author manuscript; available in PMC: 2006 Feb 17.
Published in final edited form as: Circ Res. 2005 Dec 29;98(3):386–393. doi: 10.1161/01.RES.0000201956.86258.e1

Figure 3.

Figure 3

Activation of protein kinase Cs reduces KChIP2 mRNA level. A, Neonatal myocytes were treated with 100 nmol/L PMA, 4α-PMA, or vehicle (0.1% DMSO [None]) for 8 hours in the presence of 1 μmol/L bisindolmaleimide (BIM) or vehicle (0.1% DMSO). RT-PCR results for KChIP2 variants and GAPDH are shown. Note that PMA similarly decreased 3 splicing variant mRNA levels. B, Total KChIP2 mRNA level was determined by real-time PCR. **P<0.01 (Bonferroni test, n≥6). PE-induced decrease in KChIP2 mRNA level was not significantly different between the presence and absence of BIM.