. Author manuscript; available in PMC: 2007 Feb 1.

Published in final edited form as: Mech Dev. 2006 Jan 18;123(2):124–134. doi: 10.1016/j.mod.2005.11.004

Table 1.

Effects of varying SOX10 and EDNRB dosage on hypopigmentation

		Severity of Hypopigmentation
Genotype	No.	I	II	III	IV	V
Tg(Dct-Sox10)/+^CF1-10	20	100%	0	0	0	0
Tg(Dct-Sox10)/+²²⁷²	17	100%	0	0	0	0
Tg(Dct-Sox10)/+²²⁴⁵	8	100%	0	0	0	0
Tg(Dct-Sox10)/+²²⁷⁴	14	86%	14%	0	0	0
Sox10^LacZ/+	23	39%	61%	0	0	0
Sox10^LacZ/+; Tg ^CF1-10	23	96%	4%	0	0	0
Ednrb^s/s	5	0	0	100%	0	0
Ednrb^s/s; Tg ^CF1-10	6	0	0	100%	0	0
Ednrb^s/s–l	9	0	0	0	100%	0
Ednrb^s/s–l; Tg ^CF1-10	6	0	0	0	100%	0
Ednrb^s–l/s–l	1	0	0	0	0	100%
Ednrb^s–l/s–l; Tg ^CF1-10	2	0	0	0	0	100%
Ednrb^s/+ or Ednrb^s–l/+	16	44%	56%	0	0	0
Ednrb^s/+; Tg ^CF1-10 or Ednrb^s–l/+;Tg ^CF1-10	10	20%	80%	0	0	0
Ednrb^s–l/+	23	78%	22%	0	0	0
Ednrb^s–l/+; Sox10^Dom/+	37	16%	84%	0	0	0
Sox10^Dom/+	14	7%	93%	0	0	0

No.:Number of animals used for the analysis

I: No hypopigmentation on dorsal or ventral surfaces

II: Ventral hypopigmentation only

III: Hypopigmentation over approximately 25% of the body surface area.

IV: Hypopigmentation over approximately 50 – 70% of the body surface area.

V: Hypopigmentation over approximately 95% of the body surface area.