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Changes in Scr in relation to TPM administration, and before and after hospitalization. The Scr is normal months before and after administering TPM to the patient; however, ∼13 months after starting a higher dose of TPM (day 0; hospitalization) the Scr increased acutely to 3.0 mg/dL. Post-AKI improvement in Scr is represented in the enlarged panel to the right. AKI, acute kidney injury; Scr, serum creatinine; TPM, Topiramate.
