Figure 5. Effect of α1-adrenergic agonist-stimulated on nitric oxide production.
Rat lacrimal gland acini were stimulated with phenylephrine (10−4 M) for varying times (A) or with varying concentrations of phenylephrine for 20 seconds (B) and the amount of NO was measured. (C) Acini were also preincubated with BMY-7378 (10−8 M) for 20 minutes prior to addition of phenylephrine (10−4 M) for 20 seconds. Values are mean ± SEM from 3–9 independent experiments. * indicates statistically significant difference from basal. # indicates statistically significant difference from phenylephrine alone.