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. Author manuscript; available in PMC: 2006 Feb 21.
Published in final edited form as: Ann Thorac Surg. 2005 Aug;80(2):409–417. doi: 10.1016/j.athoracsur.2005.01.048

Table 1.

Radiation and viral doses needed to kill various fractions (Fa) of A549 and H1299 cells.

Fraction Affected (Fa) Cell line Radiation alone (Gy) NV1066 alone (MOI) Radiation dose reduction index NV1066 dose reduction index Combination Index value
LD10 A549 3.2 0.0003 6160 11 0.0918
H1299 3.6 0.14 6.2 4.9 0.3669
LD20 A549 4.7 0.002 1161 10 0.1044
H1299 4.8 0.28 4.6 5.4 0.4021
LD30 A549 6 0.007 383 9 0.1150
H1299 5.8 0.45 3.8 5.8 0.4373
LD40 A549 7.5 0.02 154 8 0.1266
H1299 6.8 0.66 3.2 6 0.4748
LD50 A549 9 0.05 67 8 0.1427
H1299 7.9 0.93 2.8 6.5 0.5170
LD60 A549 10.9 0.14 29 7 0.1702
H1299 9.1 1.32 2.4 6.9 0.5679
LD70 A549 13.4 0.4 12 7 0.2306
H1299 10.7 1.93 2 7.3 0.6348
LD80 A549 17.3 1.4 4 6 0.4165
H1299 12.9 3.07 1.6 7.8 0.7355
LD90 A549 25.3 9.8 0.7 6 1.5524
H1299 17.2 6.2 1.2 8.7 0.9360

Dose reduction index is the –fold of dose reduction possible to achieve the same cell kill if radiation and virus are used in combination. LDx = Lethal dosex, dose needed to kill x% of cells, MOI = multiplicity of infection.