Table 2.

Biopsy-proven renal involvement in Legionella pneumonia: reported cases

No. [References]	Age/sex	Renal histology	Peak sCr (mg/dL)	Rhabdomyolysis (CK, U/L)	Dialysis	Steroid (regimen)	Steroid initiation	Gallium-67 scintigraphy	Outcome
1 [7]	47/M	TIN	10.7	Yes (26,021)	Yes	Yes (PSL 40 mg/day)	Day 23	No	Recovered
2 [8]	44/M	TIN	8.6	No (548)	Yes	No (antibiotics only)	–	No	Recovered
3 [9]	N/A	TIN	N/A	N/A	Yes	Yes (N/A)	N/A	No data	Recovered
4 [10]	43/M	TIN	5.3	No (N/A)	No	No (antibiotics only)	–	No	Recovered
5 [11]	26/M	TIN	12.0	Yes (8529)	Yes	No (antibiotics only)	–	No	Recovered
6 [12]	73/M	TIN	7.03	No (N/A)	Yes	No (antibiotics only)	–	No	Partial recovery
7 [13]	55/M	TIN	11.3	Yes (2000)	Yes	Yes (1 mg/kg/day)	Day 4	No	Recovered
8 [14]	51/M	TIN/ATN	4.72	No (523)	No	Yes (oral MP)	Day 4	No	Partial recovery
9 [15]	54/M	TIN	N/A	Yes (N/A)	Yes	Yes (oral MP)	N/A	No	Recovered
10 [16]	54/M	ATN	3.5	Yes (52,656)	Yes	No (antibiotics only)	–	No	Recovered
11 [17]	51/M	ATN	7.6	No (87)	No	No (antibiotics only)	–	No	Recovered
12 [18]	45/M	ATN	7.66	N/A	Yes	No (antibiotics only)	–	No	N/A
13 [19]	53/M	ATN/Myoglobin casts	9.06	Yes (16,000)	Yes	Yes (high dose) + Rituximab	Day 4	No	Recovered
Our case	73/M	ATN*	6.06	Yes (10,230)	Yes	Yes (PSL 0.5 mg/kg/day)	Day 31	Yes	Recovered

ATN, acute tubular necrosis; CK, creatine kinase; F, female; M, male; MP, methylprednisolone; N/A, not available; PSL, prednisolone; sCr, serum creatinine; TIN, tubulointerstitial nephritis

Rhabdomyolysis defined as serum CK > 1000 U/L

"Recovered": return of sCr to baseline or normal range. "Partial Recovery": improvement but persistent elevation above baseline

^*Biopsy findings also included chronic tubulointerstitial changes and a focal, reactive T-cell infiltrate (see “Discussion”)