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. 2002 Sep 1;30(17):3748–3753. doi: 10.1093/nar/gkf486

Figure 2.

Figure 2

Thermally induced strand cleavage of the alkylated 5′-Texas Red-labeled 426-bp DNA duplex by ImImPyLDu86 (14). Results using 5′- labeled top strand (pUC18 R2207–2632) (A) and 5′-labeled bottom strand (pUC18 F56–481) (B) DNA fragments are shown. These two DNA fragments are complementary sequences containing Site 1 and Site 2. Lane 1 contains the DNA control; G, C, T, A are the Sanger sequencing standards. Concentrations of conjugate 14 are indicated in lanes 2–5. Sequences containing dialkylation sites (Site 1 and Site 2) are represented (C). The arrows indicate the sites of alkylation.