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PolyPhen query processing flowchart. PolyPhen combines information on sequence features, multiple alignment with homologous proteins and structural parameters and contacts to make a prediction of nsSNP effect on protein function. hs_swall is the abbreviation for the Homo sapiens subset of the SWALL database (also known as SPTR, i.e. SwissProt + TrEMBL). Var1,2, two amino acid variants; ACC/ID, SWALL accession number or ID.
