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. 2002 Sep 1;30(17):3894–3900. doi: 10.1093/nar/gkf493

Figure 2.

Figure 2

Results of the PolyPhen analysis of the HGVbase database v.12. hs_swall denotes the Homo sapiens subset of the SWALL database. snp2prot is an in-house command line tool to map HGVbase SNPs onto sequences of known human proteins. 11 152 nsSNPs were identified. 1591 of them have been predicted as possibly damaging for protein structure and function and an additional 1257 as probably damaging. The number of structure-based predictions is much lower compared with the number of sequence-based predictions because structural information was available in only 1026 cases.