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. 2002 Sep 1;30(17):3672–3681. doi: 10.1093/nar/gkf506

Figure 7.

Figure 7

Models of two alternative modes of tetraplex d(CGG)n destabilization by CBF-A. CBF-A, schematically presented in the upper diagram with its conserved RNP boxes and ATP/GTP-binding motif, might assume either one of the two illustrated alternative conformations that conduct G′2 d(CGG)n destabilization through either RNP11 or the ATP/GTP-binding motif. (A) G′2 d(CGG)n unwinding mediated by the ATP/GTP-binding motif. The RNP11 box is blocked by the inhibitory RNP21 element (horizontal hatches) whereas the ATP/GTP-binding motif (dashed circle) remains available to conduct G′2 d(CGG)n destabilization. (B) RNP11-mediated G′2 d(CGG)n unwinding. The ATP/GTP-binding motif is blocked by the inhibitory RNP21 element (vertical hatches) whereas the RNP11 box (dashed circle) remains available to conduct G′2 d(CGG)n destabilization. Details of the models are considered in the Discussion.