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. 1993 Dec;34(12):1672–1676. doi: 10.1136/gut.34.12.1672

Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. The EUROGAST Study Group.

PMCID: PMC1374460  PMID: 8282253

Abstract

The cross sectional study describes the prevalence of infection with Helicobacter pylori as determined by a serodiagnostic assay in over 3000 asymptomatic subjects, in two age groups 25-34 years and 55-64 years, from 17 geographically defined populations in Europe, North Africa, North America, and Japan, using a common protocol for blood collection and serological testing. In all populations combined, the prevalence of infection was higher in the older age group (62.4%) than in the younger age group (34.9%). There was no difference in prevalence of infection between men and women. Subjects with higher education had considerably lower levels of infection (34.1%) compared with subjects with education up to secondary level (46.9%) or those with primary education only (61.6%). This trend was confined to the older of the two age groups. In contrast a trend of increasing prevalence of infection with increasing body mass index was confined to the younger of the two age groups. There was no effect of smoking or alcohol consumption on the prevalence of infection after adjusting for the other risk factors. There was considerable variation in the prevalence of infection between the 17 populations but, within populations, low education standard was consistently and positively associated with the prevalence of infection.

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Selected References

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  1. Fiedorek S. C., Malaty H. M., Evans D. L., Pumphrey C. L., Casteel H. B., Evans D. J., Jr, Graham D. Y. Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics. 1991 Sep;88(3):578–582. [PubMed] [Google Scholar]
  2. Forman D., Newell D. G., Fullerton F., Yarnell J. W., Stacey A. R., Wald N., Sitas F. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991 Jun 1;302(6788):1302–1305. doi: 10.1136/bmj.302.6788.1302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Galpin O. P., Whitaker C. J., Dubiel A. J. Helicobacter pylori infection and overcrowding in childhood. Lancet. 1992 Mar 7;339(8793):619–619. doi: 10.1016/0140-6736(92)90907-k. [DOI] [PubMed] [Google Scholar]
  4. Graham D. Y., Malaty H. M., Evans D. G., Evans D. J., Jr, Klein P. D., Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991 Jun;100(6):1495–1501. doi: 10.1016/0016-5085(91)90644-z. [DOI] [PubMed] [Google Scholar]
  5. Hök-Nikanne J. Effect of alcohol consumption on the risk of Helicobacter pylori infection. Digestion. 1991;50(2):92–98. doi: 10.1159/000200745. [DOI] [PubMed] [Google Scholar]
  6. Mendall M. A., Goggin P. M., Molineaux N., Levy J., Toosy T., Strachan D., Northfield T. C. Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet. 1992 Apr 11;339(8798):896–897. doi: 10.1016/0140-6736(92)90931-r. [DOI] [PubMed] [Google Scholar]
  7. Mitchell H. M., Lee A., Carrick J. Increased incidence of Campylobacter pylori infection in gastroenterologists: further evidence to support person-to-person transmission of C. pylori. Scand J Gastroenterol. 1989 May;24(4):396–400. doi: 10.3109/00365528909093065. [DOI] [PubMed] [Google Scholar]
  8. Mitchell H. M., Li Y. Y., Hu P. J., Liu Q., Chen M., Du G. G., Wang Z. J., Lee A., Hazell S. L. Epidemiology of Helicobacter pylori in southern China: identification of early childhood as the critical period for acquisition. J Infect Dis. 1992 Jul;166(1):149–153. doi: 10.1093/infdis/166.1.149. [DOI] [PubMed] [Google Scholar]
  9. Morris A., Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol. 1987 Mar;82(3):192–199. [PubMed] [Google Scholar]
  10. Moss S., Calam J. Helicobacter pylori and peptic ulcers: the present position. Gut. 1992 Mar;33(3):289–292. doi: 10.1136/gut.33.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Nomura A., Stemmermann G. N., Chyou P. H., Kato I., Perez-Perez G. I., Blaser M. J. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991 Oct 17;325(16):1132–1136. doi: 10.1056/NEJM199110173251604. [DOI] [PubMed] [Google Scholar]
  12. Parsonnet J., Blaser M. J., Perez-Perez G. I., Hargrett-Bean N., Tauxe R. V. Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterology. 1992 Jan;102(1):41–46. doi: 10.1016/0016-5085(92)91782-y. [DOI] [PubMed] [Google Scholar]
  13. Parsonnet J., Friedman G. D., Vandersteen D. P., Chang Y., Vogelman J. H., Orentreich N., Sibley R. K. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991 Oct 17;325(16):1127–1131. doi: 10.1056/NEJM199110173251603. [DOI] [PubMed] [Google Scholar]
  14. Peterson W. L. Helicobacter pylori and peptic ulcer disease. N Engl J Med. 1991 Apr 11;324(15):1043–1048. doi: 10.1056/NEJM199104113241507. [DOI] [PubMed] [Google Scholar]
  15. Sitas F., Forman D., Yarnell J. W., Burr M. L., Elwood P. C., Pedley S., Marks K. J. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut. 1991 Jan;32(1):25–28. doi: 10.1136/gut.32.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Talley N. J., Newell D. G., Ormand J. E., Carpenter H. A., Wilson W. R., Zinsmeister A. R., Perez-Perez G. I., Blaser M. J. Serodiagnosis of Helicobacter pylori: comparison of enzyme-linked immunosorbent assays. J Clin Microbiol. 1991 Aug;29(8):1635–1639. doi: 10.1128/jcm.29.8.1635-1639.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Taylor D. N., Blaser M. J. The epidemiology of Helicobacter pylori infection. Epidemiol Rev. 1991;13:42–59. doi: 10.1093/oxfordjournals.epirev.a036078. [DOI] [PubMed] [Google Scholar]
  18. al-Moagel M. A., Evans D. G., Abdulghani M. E., Adam E., Evans D. J., Jr, Malaty H. M., Graham D. Y. Prevalence of Helicobacter (formerly Campylobacter) pylori infection in Saudia Arabia, and comparison of those with and without upper gastrointestinal symptoms. Am J Gastroenterol. 1990 Aug;85(8):944–948. [PubMed] [Google Scholar]

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