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(A) Stereoview of tylosin in its binding site. The figure is based on the crystal structure (52), in which key bases are substituted for those in the Escherichia and Streptomyces rRNA sequences. (B and C) Enlargement of the targets for TlrB and TlrD methyltransferases at nucleotides G748 and A2058, respectively, showing how methylation here impinges on tylosin's binding space. The clouds indicate the van der Waals contact radii around the nucleotides atoms (not including protons).
