Table 1.
Most common proteins in drusen
| Most common protein
|
Accession no.
|
Normal donors | AMD donors | ||
|---|---|---|---|---|---|
| Match | No. | Match | No. | ||
| Normal donor drusen | |||||
| Clusterin | P10909 | 10 | 16 | 5 | 4 |
| TIMP3 | P35625 | 14 | 16 | 6 | 3 |
| Serum albumin | P02768 | 10 | 11 | 27 | 3 |
| Vitronectin | P04004 | 8 | 11 | 7 | 3 |
| Complement component 9 | P02748 | 9 | 10 | 5 | 3 |
| Actin, beta | 5 | 8 | 5 | 2 | |
| Annexin II | NP_004030 | 3 | 8 | 12 | 2 |
| Histone H2B C | Q99880 | 5 | 7 | 1 | 2 |
| Lactoglobulin, beta A chain | P02754 | 5 | 7 | 3 | 5 |
| Apolipoprotein E | 4 | 6 | 2 | 2 | |
| Complement component 3 | P01024 | 6 | 6 | ||
| Complement component 8 | P07358 | 2 | 6 | 1 | 1 |
| Histone H2Ao | P20670 | 3 | 6 | 4 | 1 |
| Serum amyloid P | 1SACA | 3 | 6 | ||
| AMBP protein | P02760 | 6 | 5 | 1 | 1 |
| Histone H2A2 | P28001 | 2 | 5 | 3 | 3 |
| Novel leucine-rich protein | 7 | 5 | |||
| Vimentin | P08670 | 4 | 5 | 4 | 2 |
| AMD donor drusen | |||||
| Crystallin, beta B1 | P53674 | 7 | 2 | 15 | 5 |
| Lactoglobulin, beta A chain | P02754 | 5 | 7 | 3 | 5 |
| Clusterin | P10909 | 10 | 16 | 5 | 4 |
| Complement component 9 | P02748 | 9 | 10 | 5 | 3 |
| Crystallin, alpha B | P02511 | 5 | 1 | 7 | 3 |
| Crystallin, beta A3 | P05813 | 4 | 1 | 8 | 3 |
| Crystallin, beta A4 | P53673 | 2 | 1 | 4 | 3 |
| Crystallin, beta B2 | P43320 | 2 | 1 | 9 | 3 |
| Crystallin, beta S | P22914 | 2 | 2 | 8 | 3 |
| Hemoglobin beta 2 | P02023 | 4 | 3 | 5 | 3 |
| Histone H2A2 | P28001 | 2 | 5 | 3 | 3 |
| Serum albumin | P02768 | 10 | 11 | 27 | 3 |
| TIMP3 | P35625 | 14 | 16 | 6 | 3 |
| Vitronectin | P04004 | 8 | 11 | 7 | 3 |
The age and sex of normal donors (n = 18) was 87F, 87M, 88F, 90F, 91F1, 91F2, 91F3, 92F1, 92F2, 92F3, 93M1, 93M2, 93M3, 94F, 96F1, 96F2, 98F1, 98F2. The age and sex of AMD donors (n = 5) was 56F, 63F, 93M, 95M, 96F. Match indicates maximum number of peptide matches identified per analysis by LC MS/MS sequence analysis. No. indicates the number of donors exhibiting the indicated protein.
*
Swiss-Protein database accession nos. are shown in regular text and National Center for Biotechnology Information database accession nos. are in italics.