Table 1.

Effect of MDL-A on JAK/STAT signal transduction of Baf/GCSFR-gp130 cells

Agents	Growth, %
Untreated	15.2  ± 0.5
GCSF, 50 ng/ml	100.0
+ MDL-A, 70 μM	108.6  ± 6.9
+ GCSFR antibody, 3 μg/ml	18.9  ± 0.2
+ Tyrphostin AG490, 10 μg/ml	13.5  ± 1.8

Chimera receptor Baf3/GCSFR-gp130 cells (1 × 10⁴ cells/200 μl per well) were incubated for 72 h with or without 70 μM MDL-A, 3 μg/ml anti-GCSFR antibody, or 10 μg/ml tyrophostin AG-490 in the presence of 50 ng/ml GCSF. Cell growth in presence of 50 ng/ml GCSF was taken as 100%. Values represent mean ± SE of three experiments. Statistical significance:

^*, P < 0.05 vs. GCSF as control.