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Regulation of Cdc25A by Chk1. Throughout the cell division cycle, Cdc25A is continually being phosphorylated by Chk1 to promote its turnover. Ionizing radiation activates a pathway that targets phosphorylated Cdc25A for complete destruction. The anticancer agent UCN-01 abrogates G2 checkpoint function by inhibiting Chk1 to deregulate the Cdc25A pathway and by inhibiting kinases other than Chk1 to deregulate the Cdc25C pathway (11).
