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. 2002 Nov 4;99(23):14807–14812. doi: 10.1073/pnas.192585799

Fig 2.

Fig 2.

Heme deficiency induces dimers and aggregates of APP in human brain cells and in rat hippocampal primary neurons. (A) Human brain cells (SHSY5Y and U373). (B) Rat hippocampal primary neurons. After induction of heme deficiency (A, 10 μM NMP for 6 days or B, different concentrations of NMP) the cells were harvested, and proteins were separated on SDS/PAGE, Western blotted, and analyzed by specific antibody for APP. The bars label APP aggregates. The data are from one of six independent experiments (human brain cells) and three experiments of hippocampal primary neurons. MWM, molecular weight markers.