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Model for the pathogenesis of t-AML
| Group | Initiating event | Impaired differentiation/ immortalization | Proliferative/ survival advantage |
|---|---|---|---|
| A1 | Unknown | ⇓ TAL1 | ⇑ FLT3 |
| ⇓ GATA1 | ⇑ PIK3C2B | ||
| ⇓ EKLF | ⇑ BCL2 | ||
| B | Mutation/ haploinsufficiency of a gene(s) on 5q | ⇓ ICSBP | ⇓ ICSBP |
| ⇑ TAL1 | ⇑ CCNA2 | ||
| ⇑ CCNE2 | |||
| ⇑ CDC2 | |||
| ⇑ MYC |
