Fig 3.

Genes involved in β-oxidation are reduced in expression as a result of aging. The transcriptional patterns also suggest that glucose utilization is increased as a result of aging. Genes encoding enzymes involved in each metabolic step are italicized. All genes shown were altered in expression as a result of aging, and the alteration in expression was either completely or partially prevented by CR. For fold-change data for each gene, and the specific percentage inhibition of the age-related change by CR, see Table 1. Fold change for phosphoglycerate kinase and enolase was 1.1-fold (P < 0.05) and is not listed in Table 1.