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. 2002 Oct 30;99(23):15078–15083. doi: 10.1073/pnas.232574499

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Copyright © 2002, The National Academy of Sciences

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Fig 4. — Properties of KAI currents in TLE mRNA-injected oocytes. KAI dose/current response relationship from 6 oocytes (3 donors; 3 patients). KAI currents were normalized to those evoked by 3 mM KAI (I_max = −239 nA). (Inset) Sample current at indicated KAI concentrations (mM). (B) Inhibition of KAI currents by CNQX. Currents evoked by KAI (200 μM) coapplied with CNQX were normalized to those evoked by KAI without CNQX (I_max = −62 nA). Same oocytes and patients as for Fig. 3A. (Inset) Superimposed currents evoked by KAI (50 μM; filled bar) and blocked by CNQX coapplication (50 μM; open bar). (C) KAI current/voltage relation for the same oocytes as in Fig. 3C. The amplitude of the currents evoked by KAI (200 μM) were normalized to the mean value obtained at −130 mV. V_rev = −4 mV.