Fig 2.

Locations of E2A-PBX1 breakpoints and V(D)J recombinase sites. Exon sequences are indicated with boxes, and intronic sequences are indicated with horizontal lines. Patient breakpoints are identified with hash marks above the introns, and putative cryptic RSS are indicated below the introns. V(D)J sites are shown with an up arrow if they are on the sense strand and a down arrow if antisense. Eighteen breakpoints within a 12-bp segment of E2A are shown as a tree-like structure, and brackets above the introns (with a *) show the clusters indicated in Results.