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. 1998 Mar;62(3):653–658. doi: 10.1086/301745

Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators.

R A Eeles 1, F Durocher 1, S Edwards 1, D Teare 1, M Badzioch 1, R Hamoudi 1, S Gill 1, P Biggs 1, D Dearnaley 1, A Ardern-Jones 1, A Dowe 1, R Shearer 1, D L McLennan 1, R L Norman 1, P Ghadirian 1, A Aprikian 1, D Ford 1, C Amos 1, T M King 1, F Labrie 1, J Simard 1, S A Narod 1, D Easton 1, W D Foulkes 1
PMCID: PMC1376940  PMID: 9497242

Abstract

Prostate cancer shows evidence of familial aggregation, particularly at young ages at diagnosis, but the inherited basis of familial prostate cancer is poorly understood. Smith et al. recently found evidence of linkage to markers on 1q, at a locus designated "HPC1," in 91 families with multiple cases of early-onset prostate cancer. Using both parametric and nonparametric methods, we attempted to confirm this finding, in 60 affected related pairs and in 76 families with three or more cases of prostate cancer, but we found no significant evidence of linkage. The estimated proportion of linked families, under a standard autosomal dominant model, was 4%, with an upper 95% confidence limit of 31%. We conclude that the HPC1 locus is responsible for only a minority of familial prostate cancer cases and that it is likely to be most important in families with at least four cases of the disease.

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Selected References

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  1. Cannon-Albright L., Eeles R. Progress in prostate cancer. Nat Genet. 1995 Apr;9(4):336–338. doi: 10.1038/ng0495-336. [DOI] [PubMed] [Google Scholar]
  2. Carter B. S., Beaty T. H., Steinberg G. D., Childs B., Walsh P. C. Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3367–3371. doi: 10.1073/pnas.89.8.3367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cooney K. A., McCarthy J. D., Lange E., Huang L., Miesfeldt S., Montie J. E., Oesterling J. E., Sandler H. M., Lange K. Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst. 1997 Jul 2;89(13):955–959. doi: 10.1093/jnci/89.13.955. [DOI] [PubMed] [Google Scholar]
  4. Eeles R. A., Dearnaley D. P., Ardern-Jones A., Shearer R. J., Easton D. F., Ford D., Edwards S., Dowe A. Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study. Br J Urol. 1997 Mar;79 (Suppl 1):8–14. doi: 10.1111/j.1464-410x.1997.tb00795.x. [DOI] [PubMed] [Google Scholar]
  5. Goldgar D. E., Easton D. F., Cannon-Albright L. A., Skolnick M. H. Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst. 1994 Nov 2;86(21):1600–1608. doi: 10.1093/jnci/86.21.1600. [DOI] [PubMed] [Google Scholar]
  6. Grönberg H., Damber L., Damber J. E. Familial prostate cancer in Sweden. A nationwide register cohort study. Cancer. 1996 Jan 1;77(1):138–143. doi: 10.1002/(SICI)1097-0142(19960101)77:1<138::AID-CNCR23>3.0.CO;2-5. [DOI] [PubMed] [Google Scholar]
  7. Kruglyak L., Daly M. J., Reeve-Daly M. P., Lander E. S. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996 Jun;58(6):1347–1363. [PMC free article] [PubMed] [Google Scholar]
  8. Kruglyak L., Lander E. S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 1995 Aug;57(2):439–454. [PMC free article] [PubMed] [Google Scholar]
  9. McIndoe R. A., Stanford J. L., Gibbs M., Jarvik G. P., Brandzel S., Neal C. L., Li S., Gammack J. T., Gay A. A., Goode E. L. Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet. 1997 Aug;61(2):347–353. doi: 10.1086/514853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Monroe K. R., Yu M. C., Kolonel L. N., Coetzee G. A., Wilkens L. R., Ross R. K., Henderson B. E. Evidence of an X-linked or recessive genetic component to prostate cancer risk. Nat Med. 1995 Aug;1(8):827–829. doi: 10.1038/nm0895-827. [DOI] [PubMed] [Google Scholar]
  11. Narod S. A., Dupont A., Cusan L., Diamond P., Gomez J. L., Suburu R., Labrie F. The impact of family history on early detection of prostate cancer. Nat Med. 1995 Feb;1(2):99–101. doi: 10.1038/nm0295-99. [DOI] [PubMed] [Google Scholar]
  12. Smith J. R., Freije D., Carpten J. D., Grönberg H., Xu J., Isaacs S. D., Brownstein M. J., Bova G. S., Guo H., Bujnovszky P. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science. 1996 Nov 22;274(5291):1371–1374. doi: 10.1126/science.274.5291.1371. [DOI] [PubMed] [Google Scholar]
  13. Steele R., Lees R. E., Kraus A. S., Rao C. Sexual factors in the epidemiology of cancer of the prostate. J Chronic Dis. 1971 Jun;24(1):29–37. doi: 10.1016/0021-9681(71)90056-7. [DOI] [PubMed] [Google Scholar]
  14. Steinberg G. D., Carter B. S., Beaty T. H., Childs B., Walsh P. C. Family history and the risk of prostate cancer. Prostate. 1990;17(4):337–347. doi: 10.1002/pros.2990170409. [DOI] [PubMed] [Google Scholar]
  15. WOOLF C. M. An investigation of the familial aspects of carcinoma of the prostate. Cancer. 1960 Jul-Aug;13:739–744. doi: 10.1002/1097-0142(196007/08)13:4<739::aid-cncr2820130414>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  16. von Eschenbach A., Ho R., Murphy G. P., Cunningham M., Lins N. American Cancer Society guidelines for the early detection of prostate cancer: update, June 10, 1997. Cancer. 1997 Nov 1;80(9):1805–1807. doi: 10.1002/(sici)1097-0142(19971101)80:9<1805::aid-cncr17>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]

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