Table 2.
Pharmacological profiling of DrmFMRFa-R
| Peptide | Sequence | EC50, nM |
|---|---|---|
| Drm-FMRFamide-1 | DPKQDFMRF-NH2 | 2.0 |
| Drm-FMRFamide-2 | TPAEDFMRF-NH2 | 2.8 |
| Drm-FMRFamide-3 | SDNFMRF-NH2 | 1.9 |
| Drm-FMRFamide-4 | SPKQDFMRF-NH2 | 2.5 |
| Drm-FMRFamide-5 | PDNFMRF-NH2 | 1.8 |
| [Ala4] Drm-FMRFa3 | SDNAMRF-NH2 | 102 |
| [Ala4] Drm-FMRFa5 | PDNAMRF-NH2 | 64 |
| Neb-FIRFamide | APPQPSDNFIRF-NH2 | 3.5 |
| Neb-FMRFamide | pQPSQDFMRF-NH2 | 2.0 |
| Drm-sNPF-1 | AQRSPSLRLRF-NH2 | 270 |
| Drm-SK-1 | FDDYGHMRF-NH2 | 38 |
| Drm-SK-2 | GGDDQFDDYGHMRF-NH2 | 105 |
| Drm-MS | TDVDHVFLRF-NH2 | 91 |
| Scg-FLRFamide | PDVDHVFLRF-NH2 | 25 |
| Pev-SK | AGGSGGVGGEYDDYGHLRF-NH2 | 85 |
| FMRFamide | FMRF-NH2 | 28 |
| AMRFamide | AMRF-NH2 | 3,217 |
| YMRFamide | YMRF-NH2 | 31 |
| MRFamide | MRF-NH2 | 6,416 |
| RFamide | RF-NH2 | n.a. |
| Lom-MIP | AWQDLNAGW-NH2 | n.a. |
| Pev-PK 2 | ADFAFNPRL-NH2 | n.a. |
| Corazonin | pQTFQWSHGWTN-NH2 | n.a. |
n.a., not active up to 10 μM. The Y residues of the sulfakinins indicated in bold are sulfated.