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(A) Close-up view of the ELR motif. R93 is in the middle of a hydrogen-bonding network involving G46, A340, and Y341. G46 is located on a loop that is only three residues before the HIGH tetrapeptide (HAVY in human TyrRS). A340 and Y341 are from α14 of the anticodon-recognition domain. (B) Partial sequence alignment of TyrRS from eukaryotes (except plants) indicating all four residues (red) involved in the above hydrogen-bonding network are conserved. HAVY is colored in blue.
